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Int J Cancer. 2019 Feb 14. doi: 10.1002/ijc.32210. [Epub ahead of print]

Change in mammographic density across birth cohorts of Dutch breast cancer screening participants.

Author information

1
Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
2
Nykøbing Falster Hospital, University of Copenhagen, Copenhagen, Denmark.
3
Department of Computer Sciences, University of Copenhagen, Copenhagen, Denmark.
4
Department of Radiology, University Hospital Copenhagen, Copenhagen, Denmark.
5
Department of Epidemiology, Julius Center for Health, Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
6
Department of Radiology and Nuclear Medicine, Radboud University, Medical Center, Nijmegen, The Netherlands.

Abstract

High mammographic density is a well-known risk factor for breast cancer. This study aimed to search for a possible birth cohort effect on mammographic density, which might contribute to explain the increasing breast cancer incidence. We separately analyzed left and right breast density of Dutch women from a 13-year period (2003-2016) in the breast cancer screening programme. First, we analyzed age-specific changes in average percent dense volume (PDV) across birth cohorts. A linear regression analysis (PDV vs. year of birth) indicated a small but statistically significant increase in women of: 1) age 50 and born from 1952 to 1966 (left, slope = 0.04, p = 0.003; right, slope = 0.09, p < 0.0001); 2) age 55 and born from 1948 to 1961 (right, slope = 0.04, p = 0.01); and 3) age 70 and born from 1933 to 1946 (right, slope = 0.05, p = 0.002). A decrease of total breast volume seemed to explain the increase in PDV. Second, we compared proportion of women with dense breast in women born in 1946-1953 and 1959-1966, and observed a statistical significant increase of proportion of highly dense breast in later born women, in the 51 to 55 age-groups for the left breast (around a 20% increase in each age-group), and in the 50 to 56 age-groups for the right breast (increase ranging from 27% to 48%). The study indicated a slight increase in mammography density across birth cohorts, most pronounced for women in their early 50s, and more marked for the right than for the left breast.

KEYWORDS:

breast cancer screening; mammographic density; secular trends; volumetric breast density

PMID:
30762225
DOI:
10.1002/ijc.32210

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