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Ann Rheum Dis. 2019 May;78(5):590-593. doi: 10.1136/annrheumdis-2018-214514. Epub 2019 Feb 13.

Prevotella copri in individuals at risk for rheumatoid arthritis.

Author information

1
Division of Rheumatology, Geneva University Hospital, Geneva, Switzerland.
2
Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.
3
Division of Rheumatology, Geneva University Hospital, Geneva, Switzerland axel.finckh@hcuge.ch Till.Strowig@helmholtz-hzi.de.
4
Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany axel.finckh@hcuge.ch Till.Strowig@helmholtz-hzi.de.
5
Hannover Medical School, Hannover, Germany.
#
Contributed equally

Abstract

OBJECTIVES:

Rheumatoid arthritis (RA) has been associated with a relative expansion of faecal Prevotellaceae. To determine the microbiome composition and prevalence of Prevotella spp. in a group of individuals at increased risk for RA, but prior to the development of the disease.

METHODS:

In an ongoing cohort study of first-degree relatives (FDRs) of patients with RA, we identified 'FDR controls', asymptomatic and without autoantibodies, and individuals in pre-clinical RA stages, who had either developed anticitrullinated peptide antibodies or rheumatoid factor positivity and/or symptoms and signs associated with possible RA. Stool sampling and culture-independent microbiota analyses were performed followed by descriptive statistics and statistical analyses of community structures.

RESULTS:

A total of 133 participants were included, of which 50 were categorised as 'FDR controls' and 83 in 'pre-clinical RA stages'. The microbiota of individuals in 'pre-clinical RA stages' was significantly altered compared with FDR controls. We found a significant enrichment of the bacterial family Prevotellaceae, particularly Prevotella spp., in the 'pre-clinical RA' group (p=0.04).

CONCLUSIONS:

Prevotella spp. enrichment in individuals in pre-clinical stages of RA, before the onset of RA, suggests a role of intestinal dysbiosis in the development of RA.

KEYWORDS:

epidemiology of ra; microbiome; pre-clinical stages of ra; rheumatoid arthritis

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