Format

Send to

Choose Destination
Sci Rep. 2019 Feb 12;9(1):1842. doi: 10.1038/s41598-018-37734-w.

Ventricular-Subventricular Zone Contact by Glioblastoma is Not Associated with Molecular Signatures in Bulk Tumor Data.

Author information

1
Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
2
Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
3
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA.
4
Department of Radiology, Vanderbilt University Medical Center, Nashville, TN, USA.
5
Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
6
Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA. rebecca.ihrie@vanderbilt.edu.
7
Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA. rebecca.ihrie@vanderbilt.edu.
8
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. rebecca.ihrie@vanderbilt.edu.

Abstract

Whether patients with glioblastoma that contacts the ventricular-subventricular zone stem cell niche (VSVZ + GBM) have a distinct survival profile from VSVZ - GBM patients independent of other known predictors or molecular profiles is unclear. Using multivariate Cox analysis to adjust survival for widely-accepted predictors, hazard ratios (HRs) for overall (OS) and progression free (PFS) survival between VSVZ + GBM and VSVZ - GBM patients were calculated in 170 single-institution patients and 254 patients included in both The Cancer Genome (TCGA) and Imaging (TCIA) atlases. An adjusted, multivariable analysis revealed that VSVZ contact was independently associated with decreased survival in both datasets. TCGA molecular data analyses revealed that VSVZ contact by GBM was independent of mutational, DNA methylation, gene expression, and protein expression signatures in the bulk tumor. Therefore, while survival of GBM patients is independently stratified by VSVZ contact, with VSVZ + GBM patients displaying a poor prognosis, the VSVZ + GBMs do not possess a distinct molecular signature at the bulk sample level. Focused examination of the interplay between the VSVZ microenvironment and subsets of GBM cells proximal to this region is warranted.

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center