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Clin Infect Dis. 2019 Feb 12. doi: 10.1093/cid/ciz134. [Epub ahead of print]

Transmission-blocking effects of primaquine and methylene blue suggest P. falciparum gametocyte sterilisation rather than effects on sex ratio.

Author information

1
MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom.
2
Malaria Research and Training Centre, Faculty of Pharmacy and Faculty of Medicine and Dentistry, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.
3
Global Health Group, Malaria Elimination Initiative, University of California San Francisco, San Francisco, CA, USA.
4
Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom.
5
MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, United Kingdom.
6
Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, the Netherlands.

Abstract

Gametocyte density and sex-ratio can predict the proportion of mosquitoes that become infected after feeding on blood of patients receiving non-gametocytocidal drugs. Because primaquine and methylene blue sterilize gametocytes before affecting their density and sex-ratio, mosquito feeding experiments are required to demonstrate their early transmission-blocking effects.

PMID:
30753355
DOI:
10.1093/cid/ciz134

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