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J Enzyme Inhib Med Chem. 2019 Dec;34(1):651-656. doi: 10.1080/14756366.2019.1574297.

Synthesis and biological evaluation of 3-arylcoumarins as potential anti-Alzheimer's disease agents.

Yang J1,2,3,4, Zhang P1,2,3,4, Hu Y1,2,3,4, Liu T1,2,3,4, Sun J1,2,3,4, Wang X1,2,3,4.

Author information

1
a School of Medicine and Life Sciences , University of Jinan-Shandong Academy of Medical Sciences , Jinan , China.
2
b Institute of MateriaMedica , Shandong Academy of Medical Sciences , Jinan , China.
3
c Key Laboratory for Biotech-Drugs Ministry of Health , Jinan , China.
4
d Key Laboratory for Rare & Uncommon Diseases of Shandong Province , Jinan , China.

Abstract

Alzheimer's disease, a neurodegenerative illness, has the extremely complex pathogenesis. Accumulating evidence indicates there is a close relationship between several enzymes and Alzheimer's disease. Various substituted 3-arylcoumarin derivatives were synthesised, and their in vitro activity, including cholinesterase inhibitory activity, monoamine oxidase inhibitory activity, and antioxidant activity were investigated. Most of the compounds exhibited high activity; therefore 3-arylcoumarin compounds have the potential as drug candidates for the treatment of Alzheimer's disease.

KEYWORDS:

3-Arylcoumarin; Alzheimer’s disease; antioxidant activity; cholinesterase inhibitors; monoamine oxidase inhibitors

PMID:
30746966
PMCID:
PMC6374920
DOI:
10.1080/14756366.2019.1574297
[Indexed for MEDLINE]
Free PMC Article

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