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Protein Sci. 2019 Apr;28(4):678-683. doi: 10.1002/pro.3588.

What has de novo protein design taught us about protein folding and biophysics?

Author information

1
Department of Biochemistry, University of Washington, Box 357350, 1705 NE Pacific Street, Seattle, Washington, 98195-7350, USA.

Abstract

Recent progress in de novo protein design has led to an explosion of new protein structures, functions and assemblies. In this essay, I consider how the successes and failures in this new area inform our understanding of the proteins in nature and, more generally, the predictive computational modeling of biological systems.

KEYWORDS:

computational modeling; protein design; protein folding

PMID:
30746840
PMCID:
PMC6423711
[Available on 2020-04-01]
DOI:
10.1002/pro.3588

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