Format

Send to

Choose Destination
J Med Imaging (Bellingham). 2019 Jul;6(3):031405. doi: 10.1117/1.JMI.6.3.031405. Epub 2019 Jan 31.

Prediction of reader estimates of mammographic density using convolutional neural networks.

Author information

1
University of Manchester, School of Computer Science, Manchester, United Kingdom.
2
University of Manchester, Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, Manchester, United Kingdom.
3
University of Manchester, School of Biological Sciences, Division of Neuroscience and Experimental Psychology, Manchester, United Kingdom.
4
University of Manchester, Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.
5
Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Prevent Breast Cancer and Nightingale Breast Screening Centre, Wythenshawe, Manchester, United Kingdom.
6
Queen Mary University of London, Wolfson Institute of Preventive Medicine, Centre for Cancer Prevention, London, United Kingdom.
7
The Christie NHS Foundation Trust, Manchester Academic Health Science Centre, Withington, Manchester, United Kingdom.
8
University of Manchester and Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, Genomic Medicine, Division of Evolution and Genomic Science, Manchester, Manchester, United Kingdom.

Abstract

Mammographic density is an important risk factor for breast cancer. In recent research, percentage density assessed visually using visual analogue scales (VAS) showed stronger risk prediction than existing automated density measures, suggesting readers may recognize relevant image features not yet captured by hand-crafted algorithms. With deep learning, it may be possible to encapsulate this knowledge in an automatic method. We have built convolutional neural networks (CNN) to predict density VAS scores from full-field digital mammograms. The CNNs are trained using whole-image mammograms, each labeled with the average VAS score of two independent readers. Each CNN learns a mapping between mammographic appearance and VAS score so that at test time, they can predict VAS score for an unseen image. Networks were trained using 67,520 mammographic images from 16,968 women and for model selection we used a dataset of 73,128 images. Two case-control sets of contralateral mammograms of screen detected cancers and prior images of women with cancers detected subsequently, matched to controls on age, menopausal status, parity, HRT and BMI, were used for evaluating performance on breast cancer prediction. In the case-control sets, odd ratios of cancer in the highest versus lowest quintile of percentage density were 2.49 (95% CI: 1.59 to 3.96) for screen-detected cancers and 4.16 (2.53 to 6.82) for priors, with matched concordance indices of 0.587 (0.542 to 0.627) and 0.616 (0.578 to 0.655), respectively. There was no significant difference between reader VAS and predicted VAS for the prior test set (likelihood ratio chi square, p = 0.134 ). Our fully automated method shows promising results for cancer risk prediction and is comparable with human performance.

KEYWORDS:

breast cancer; deep learning; mammographic density; risk; visual analogue scales

PMID:
30746393
PMCID:
PMC6357906
[Available on 2020-01-31]
DOI:
10.1117/1.JMI.6.3.031405

Supplemental Content

Loading ...
Support Center