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Diagn Pathol. 2019 Feb 11;14(1):17. doi: 10.1186/s13000-019-0795-3.

Concurrent isolated retroperitoneal HGSC and STIC defined by somatic mutation analysis: a case report.

Author information

1
Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan.
2
Department of Genetics, School of Life Sciences, Graduate University for Advanced Studies (SOKENDAI), Hayama, Japan.
3
Division of Human Genetics, National Institute of Genetics, Mishima, Japan.
4
Department of Obstetrics and Gynecology, Niigata Prefectural Shibata Hospital, Shibata, Japan.
5
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
6
Department of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
7
Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan. yoshikou@med.niigata-u.ac.jp.

Abstract

BACKGROUND:

Retroperitoneal high-grade serous carcinoma (HGSC) is extremely rare and the origin remains unclear. We present a case of retroperitoneal HGSC and coexisting serous tubal intraepithelial carcinoma (STIC), which is considered as the main origin of ovarian HGSC. We reviewed the available literature and discussed about the origin of this rare disease.

CASE PRESENTATION:

A 58-year-old female with a 93 × 65 × 62 mm-solid tumor with a cystic part was located immediately dorsal to the rectum underwent bilateral salpingo-oophorectomy, total abdominal hysterectomy, and en bloc resection of the retroperitoneal tumor together with lower anterior resection of the rectum. Histological diagnosis was retroperitoneal HGSC and STIC at the right fallopian tube. Two deleterious somatic mutations in TP53 and BRCA2 genes were shared between retroperitoneal HGSC and STIC.

CONCLUSIONS:

In addition to clinical features in the previous reports, our genetic findings suggest the origin of retroperitoneal HGSC might be STIC.

KEYWORDS:

Case report; Retroperitoneal high-grade serous carcinoma; Serous tubal intraepithelial carcinoma; Somatic mutation

PMID:
30744657
PMCID:
PMC6371506
DOI:
10.1186/s13000-019-0795-3
[Indexed for MEDLINE]
Free PMC Article

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