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Materials (Basel). 2019 Feb 10;12(3). pii: E528. doi: 10.3390/ma12030528.

Preparation and Characterization of Poly(δ-Valerolactone)/TiO2 Nanohybrid Material with Pores Interconnected for Potential Use in Tissue Engineering.

Author information

1
Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. wsaeed@ksu.edu.sa.
2
Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. aalodayni@ksu.edu.sa.
3
Restorative Dental Sciences Department, Engineer Abdullah Bugshan research chair for Dental and Oral Rehabilitation College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia. aalghamdia@ksu.edu.sa.
4
Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. taouak@ksu.edu.sa.

Abstract

Titanium dioxide/poly(δ-valerolactone) (TiO₂/Pδ-VL) nanohybrid material containing interconnected pores with sizes in the range 80⁻150 μm were prepared by the solvent casting and polymer melting routes, and the dispersion of the TiO₂ nanofiller in the Pδ-VL matrix and its adhesion were characterized by X-ray diffraction, differential scanning calorimetry, and scanning electron microscopy. A significant depression in the glass transition temperature (Tg) and melting temperature (Tm) values were revealed for the polymer nanocomposites prepared by the solvent casting technique. For the potential application of the prepared materials in the biomedical domain, complementary analyses were performed to examine the dynamic mechanical properties, and cell adhesion (using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay), and the results obtained for the samples prepared by the two methods were compared. Interconnected pores were successively produced in the new material by employing naphthalene microparticles as a porogen for the first time, and the results obtained were very promising.

KEYWORDS:

Tissue Engineering; cell adhesion; mechanical properties; poly(δ-valerolactone)/titanium oxide nanocomposite; pore connection

Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analysis, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

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