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J Cyst Fibros. 2019 Mar;18(2):294-298. doi: 10.1016/j.jcf.2018.10.011. Epub 2018 Oct 25.

Cystic fibrosis related diabetes is not independently associated with increased Stenotrophomonas maltophilia infection: Longitudinal data from the UK CF Registry.

Author information

1
Adult Cystic Fibrosis Centre, Liverpool Heart and Chest Hospital, Liverpool L14 3PE, UK. Electronic address: Frost@lhch.nhs.uk.
2
Adult Cystic Fibrosis Centre, Liverpool Heart and Chest Hospital, Liverpool L14 3PE, UK. Electronic address: Dilip.Nazareth@lhch.nhs.uk.
3
Research Department, Liverpool Heart and Chest Hospital, Liverpool L14 3PE, UK. Electronic address: Matt.Shaw@lhch.nhs.uk.
4
Adult Cystic Fibrosis Centre, Liverpool Heart and Chest Hospital, Liverpool L14 3PE, UK. Electronic address: Martin.Walshaw@lhch.nhs.uk.

Abstract

INTRODUCTION:

Stenotrophomonas maltophilia is common in the sputum of people with cystic fibrosis related diabetes (CFRD), raising the question as to whether this is a risk factor for its acquisition. We investigated this at a population level.

METHODS:

We analysed national Cystic Fibrosis Registry data 2011-2015 for 8047 people with CF > age 6 years, looking at demographics, diagnosis of CFRD, lung function and sputum microbiology; using descriptive and multivariate strategies to establish independent predictors for S. maltophilia culture and associated outcomes.

RESULTS:

S. maltophilia was present in 1148 (14.1%). Although univariate analysis confirmed it was more prevalent in those with CFRD, when adjusted for other clinical parameters there was no longer a relationship. Markers of more severe lung disease were independent risk-factors for S. maltophilia.

CONCLUSION:

Although S. maltophilia is more common in people with CFRD, it is not an independent risk-factor for S. maltophilia acquisition.

PMID:
30741162
DOI:
10.1016/j.jcf.2018.10.011

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