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Br J Nutr. 2019 May;121(9):1039-1048. doi: 10.1017/S0007114518003860. Epub 2019 Feb 11.

Associations between urinary iodine concentration, lipid profile and other cardiometabolic risk factors in adolescents: a cross-sectional, population-based analysis.

Author information

1
1Department of Endocrinology,Beijing Hospital,National Center of Gerontology, no. 1, Dahua Road, Dongcheng District, Beijing 100730,People's Republic of China.
2
2The Key Laboratory of Geriatrics,Beijing Hospital and Beijing Institute of Geriatrics,National Center of Gerontology, no. 1, Dahua Road, Dongcheng District, Beijing 100730,People's Republic of China.

Abstract

Low urinary iodine concentration (UIC) is associated with dyslipidaemia in adults but is not well characterised in adolescents. Because dyslipidaemia is a cardiovascular risk factor, identifying such an association in adolescents would allow for the prescription of appropriate measures to maintain cardiovascular health. The present study addresses this question using data in the 2001-2012 National Health and Nutrition Examination Survey for 1692 adolescents aged 12-19 years. Primary outcomes were UIC, cardiometabolic risk factors and dyslipidaemia. Data for subjects categorised by low and normal UIC and by sex were analysed by univariate and multivariate logistic regression. Treating UIC as the independent variable, physical activity level, apoB and lipid profiles differed significantly between subjects with low and normal UIC. Subjects with low UIC had a significantly greater risk of elevated total cholesterol (TC) (95 % CI 1·37, 2·81), elevated non-HDL (95 % CI 1·33, 2·76) and elevated LDL (95 % CI 1·83, 4·19) compared with those with normal UIC. Treating UIC as a dependent variable, the risk of low UIC was significantly greater in those with higher apoB (95 % CI 1·52, 19·08), elevated TC (≥4·4mmol/l) (95 % CI 1·37, 2·81) and elevated non-HDL (≥3·11mmol/l) (95 % CI 1·33, 2·76) than in those with normal UIC. These results show that male and female adolescents with low UIC tend to be at greater risk of dyslipidaemia and abnormal cardiometabolic biomarkers, though the specific abnormal parameters differed between sexes. These results may help to identify youth who would benefit from interventions to improve their cardiometabolic risk.

KEYWORDS:

CDC Centers for Disease Control and Prevention; MET metabolic equivalent of task; NHANES National Health and Nutrition Examination Survey; TC total cholesterol; UIC urinary iodine concentration; Cardiometabolic risk factors; National Health and Nutrition Examination Survey; Thyroid hormones; Urinary iodine

PMID:
30739611
DOI:
10.1017/S0007114518003860

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