Format

Send to

Choose Destination
Hypertension. 2019 Apr;73(4):803-811. doi: 10.1161/HYPERTENSIONAHA.118.12305.

Greater Blood Pressure Variability Is Associated With Lower Cognitive Performance.

Author information

1
From the Department of Internal Medicine (T.L.Z., A.A.K., M.T.S., C.D.A.S., R.M.A.H.), Maastricht University Medical Centre, the Netherlands.
2
CARIM School for Cardiovascular Diseases (T.L.Z., A.A.K., T.T.v.S., M.T.S., C.D.A.S., R.M.A.H.), Maastricht University, the Netherlands.
3
Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, France (T.T.v.S.).
4
Department of Epidemiology and Department of Arterial Mechanics, INSERM, UMR-S970, Paris Cardiovascular Research Center, France (T.T.v.S.).
5
Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg (M.P.J.v.B., F.R.J.V., S.K.), Maastricht University Medical Centre, the Netherlands.
6
MHeNs School for Mental Health and Neuroscience (M.P.J.v.B., F.R.J.V., S.K.), Maastricht University, the Netherlands.
7
Heart and Vascular Centre (M.T.S., R.M.A.H.), Maastricht University Medical Centre, the Netherlands.

Abstract

An increasing number of individuals will face age-related cognitive difficulties because life expectancy has increased. It is, therefore, important to identify modifiable risk factors for cognitive impairment. Very short-term to mid-term blood pressure variability (BPV) may be such a factor because it may cause cerebral ischemia. To this end, we investigated whether greater systolic and diastolic BPV are cross-sectionally associated with memory function (n=1804), information processing speed (n=1793), and executive function (n=1780) in 40- to 75-year-old individuals from The Maastricht Study. A composite BPV-index was derived by standardizing within-visit, 24-hour, and 7-day BPV. We performed linear regression with adjustments for age, sex, educational level, 24-hour systolic or diastolic pressure, and cardiovascular risk factors. We found that a 1-SD greater systolic BPV was not associated with information processing speed (β [SD difference], -0.10; 95% CI, -0.14 to 0.06), or executive function (-0.09; 95% CI, -0.20 to 0.02) but was marginally associated with lower memory function (-0.11; 95% CI, -0.21 to 0.00). A 1-SD greater diastolic BPV was associated with lower information processing speed (-0.10; 95% CI, -0.20 to -0.00) and executive function (-0.12; 95% CI, -0.22 to -0.01) and marginally associated with lower memory function (-0.09; 95% CI, -0.20 to 0.01). These effects on cognitive performance are equivalent to ≈3 additional years of aging. In conclusion, greater very short-term to mid-term diastolic and, to a lesser extent, systolic BPV may be a modifiable risk factor for cognitive deterioration in 40- to 75-year-old, community-dwelling individuals.

KEYWORDS:

aging; blood pressure; executive function; memory; risk factor

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center