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J Colloid Interface Sci. 2019 Feb 4;542:198-206. doi: 10.1016/j.jcis.2019.02.010. [Epub ahead of print]

Benzoxazine monomer derived carbon dots as a broad-spectrum agent to block viral infectivity.

Author information

1
State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China; The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.
2
College of Science, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China. Electronic address: jiangjianggu@mail.hzau.edu.cn.
3
College of Science, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.
4
Wuhan Brain VTA Technology Co. Ltd., Wuhan, Hubei 430070, PR China.
5
State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China; The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China. Electronic address: sbcao@mail.hzau.edu.cn.

Abstract

Multiple viruses can cause infection and death of millions annually. Of these, flaviviruses are found to be highly prevalent in recent years with no distinctive antiviral therapies. Therefore, there is a desperate need for broad-spectrum antiviral drugs that can be active against a large number of existing and emerging viruses. Herein, we prepared a kind of benzoxazine monomer derived carbon dots (BZM-CDs) and demonstrated their infection-blocking ability against life-threatening flaviviruses (Japanese encephalitis, Zika, and dengue viruses) and non-enveloped viruses (porcine parvovirus and adenovirus-associated virus). It was found that BZM-CDs could directly bind to the surface of the virion, and eventually the first step of virus-cell interaction was impeded. The developed nanoparticles are active against both flaviviruses and non-enveloped viruses in vitro. Thus, the application of BZM-CDs may constitute an intriguing broad-spectrum approach to rein in viral infections.

KEYWORDS:

Antivirus; Benzoxazine monomers; Broad-spectrum agents; Carbon dots; Flaviviruses

PMID:
30739009
DOI:
10.1016/j.jcis.2019.02.010

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