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Curr Opin Neurobiol. 2019 Feb 6;57:39-45. doi: 10.1016/j.conb.2019.01.003. [Epub ahead of print]

Microtubule control of functional architecture in neurons.

Author information

1
Integrated Program in Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Biochemistry Department, University of Wisconsin-Madison, Madison, WI 53706, USA.
2
Biochemistry Department, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address: wildonger@wisc.edu.

Abstract

Neurons are exquisitely polarized cells whose structure and function relies on microtubules. Microtubules in signal-receiving dendrites and signal-sending axons differ in their organization and microtubule-associated proteins. These differences, coupled with microtubule post-translational modifications, combine to locally regulate intracellular transport, morphology, and function. Recent discoveries provide new insight into the regulation of non-centrosomal microtubule arrays in neurons, the relationship between microtubule acetylation and mechanosensation, and the spatial patterning of microtubules that regulates motor activity and cargo delivery in axons and dendrites. Together, these new studies bring us closer to understanding how microtubule function is locally tuned to match the specialized tasks associated with signal reception and transmission.

PMID:
30738328
DOI:
10.1016/j.conb.2019.01.003
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