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Mech Ageing Dev. 2019 Feb 6;179:23-35. doi: 10.1016/j.mad.2019.02.001. [Epub ahead of print]

Comparative analysis of the gut microbiota in centenarians and young adults shows a common signature across genotypically non-related populations.

Author information

1
Microbial Resources Division, Institute of Bioresources and Sustainable Development (IBSD), Takyelpat Institutional Area, Imphal, 795 001, Manipur, India; Department of Biotechnology, Gauhati University, Guwahati, 781 014, Assam, India.
2
Microbial Resources Division, Institute of Bioresources and Sustainable Development (IBSD), Takyelpat Institutional Area, Imphal, 795 001, Manipur, India.
3
Distributed Information Sub-Centre (DISC), Institute of Bioresources and Sustainable Development (IBSD), Takyelpat Institutional Area, Imphal, 795 001, Manipur, India.
4
Mass Spectrometry (Metabolomics) Facility, Centre for Cellular and Molecular Platforms (C-CAMP), Bengaluru, 560065, Karnataka, India.
5
Department of Anthropology, Manipur University, Canchipur, Imphal, 795003, Manipur, India.
6
Department of Biotechnology, Gauhati University, Guwahati, 781 014, Assam, India.
7
Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Bologna, 40126, Italy.
8
Microbial Resources Division, Institute of Bioresources and Sustainable Development (IBSD), Takyelpat Institutional Area, Imphal, 795 001, Manipur, India. Electronic address: jeyaram.ibsd@nic.in.

Abstract

Gut microbiota is among the factors that may be involved in healthy aging. Broader and geographically spread studies on gut microbiota of centenarians can help in identifying a common signature of longevity. We identified an endogamous Indian population with high centenarian prevalence. Here, we compared the gut microbiota composition and fecal metabolites of a centenarians group (˜100 years) with young people (25-45 years) of the region with the high centenarian prevalence and the nearby region of low centenarian prevalence to decipher microbial-related longevity signatures. Also, we compared our results with publicly available datasets of similar groups including 125 centenarians from three countries (Italy, Japan, China). Our comparative analysis resulted in higher biodiversity within Ruminococcaceae in centenarians, with respect to younger adults, irrespective of their nationality. We observed bacterial signatures that are common among extremely old people of different nationality. Comparative metabolites profiling identified the fecal metabolic signature of extreme aging in the Indian study population. Our analysis of the co-occurrence network and bimodal distribution of several taxa suggested the establishment of a pervasive change in the gut ecology during extreme aging. Our study might pave the way to develop gut microbiota based biomarkers for healthy aging.

KEYWORDS:

Butyrate; Centenarians; Faecal metabolites; Gut microbiota; Longevity; Naga community; Ruminococcaceae

PMID:
30738080
DOI:
10.1016/j.mad.2019.02.001

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