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J Ovarian Res. 2019 Feb 8;12(1):15. doi: 10.1186/s13048-019-0486-4.

Progesterone reduces cell survival in primary cultures of endometrioid ovarian cancer.

Author information

1
Departamento de Embriología, Facultad de Medicina, Universidad Nacional Autónoma de México, 04510, Ciudad de México, Mexico.
2
Departamento de Oncología Médica, Instituto Nacional de Cancerología, Secretaría de Salud de México, Ciudad de México, Mexico.
3
Departamento de Patología, Instituto Nacional de Cancerología, Secretaría de Salud de México, Ciudad de México, Mexico.
4
Departamento de Embriología, Facultad de Medicina, Universidad Nacional Autónoma de México, 04510, Ciudad de México, Mexico. mendezmc@unam.mx.

Abstract

BACKGROUND:

Ovarian cancer is the most lethal of all gynecologic malignancies. The relationship between sexual steroids receptors and ovarian cancer progression has been largely evaluated. The presence of progesterone receptors has been associated with an increase of a disease-free period and overall survival in patients with ovarian carcinoma. In the present study, primary cultures of ovarian carcinoma obtained from 35 patients diagnosed with epithelial ovarian cancer were evaluated for cell survival after treatment with 10- 8 M of 17β-estradiol, progesterone, testosterone and dihydrotestosterone.

RESULTS:

The results were analyzed considering histological subtypes: low grade serous, high grade serous, endometrioid and mucinous carcinoma; clear cell carcinoma was not included due to failure in obtaining successful cultures of this subtype. A significant reduction of cell survival was observed after progesterone treatment in endometrioid ovarian carcinoma. Changes were not observed in low grade serous, high grade serous and mucinous carcinoma. The effect of progesterone was related to the presence of progesterone receptor (PR), a 43% reduction in the cell number was observed in PR (+) endometrioid ovarian carcinoma.

CONCLUSIONS:

This study supports the importance of progesterone and the presence of progesterone receptor in the reduction of ovarian cancer progression in the endometrioid ovarian carcinoma.

KEYWORDS:

Cell survival; Endometrioid ovarian carcinoma; Ovarian cancer; Primary cell culture; Progesterone; Steroid hormones

PMID:
30736825
PMCID:
PMC6367846
DOI:
10.1186/s13048-019-0486-4
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