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J Mech Behav Biomed Mater. 2019 Apr;92:179-187. doi: 10.1016/j.jmbbm.2019.01.017. Epub 2019 Jan 30.

Tough robust dual responsive nanocomposite hydrogel as controlled drug delivery carrier of asprin.

Author information

1
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
2
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. Electronic address: yjr@dhu.edu.cn.

Abstract

Smart mechanical strong hydrogels have gained increasing attention in the last decade. A novel tough robust biocompatible and dual pH- and temperature- responsive poly (N-isopropylacrylamide)/clay (Laponite XLS)/gold nanoparticles (Au-S-S NPs)/caboxymethyl chitosan (CMCTs) nanocomposite hydrogel was synthesized by a facile one-pot in situ free radical polymerization, using clay and Au-S-S NPs as the cross-linkers instead of toxic organic molecules. By tuning the crucial factors, concentration of Au-S-S NPs, CMCTs and clay, the obtained hydrogels exhibited the highest tensile stress of 535.5 kPa at the breaking deformation of 1579.5%. Furthermore, these synthesized hydrogels were tough enough and simultaneously owned a fast recoverability after unloaded in 15 min at room temperature. Moreover, effects of the above factors on swelling and swelling-shrinking behaviors of the prepared hydrogels were investigated in detail. In addition, these designed hydrogels also possessed a controlled drug release property of asprin by adjusting their inner crosslink density. Owing to this property, they could be used as the potential drug delivery carriers in future.

KEYWORDS:

Biocompatible; Carboxymethyl chitosan; Drug delivery carriers; Hydrogel; Robust

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