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Food Chem Toxicol. 2019 Mar;125:494-502. doi: 10.1016/j.fct.2019.01.037. Epub 2019 Feb 5.

Antidiabetic effect of quercetin: A systematic review and meta-analysis of animal studies.

Author information

1
The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia.
2
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
3
The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
4
The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran; Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: mohammad@tums.ac.ir.
5
The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: moamini@tums.ac.ir.

Abstract

Quercetin is a plant polyphenol with biological activities such as anti-inflammatory, anticancer, antidiabetic, neuroprotective and anti-allergic. The objective of this review is to provide a systematic evaluation of the evidence and a meta-analysis of data from previously published researches on the antidiabetic action of quercetin. A comprehensive literature search was conducted between July 2018 and August 2018 on PubMed, EMBASE, Web of Sciences and Scopus databases. A random-effects model was used to estimate the pooled effect size and studies were weighted according to an estimate of the mean difference. The heterogeneity between studies was assessed using a Higgins' I2 test with corresponding p values. Overall 13 eligible articles with appropriate data on serum glucose were included in the statistical analysis. The meta-analysis for serum glucose level (mg/dL) showed that at doses of 10, 25 and 50 mg/kg there was a significant difference between the means. Therefore, the results of the meta-analysis support the hypothesis that quercetin lowers serum glucose level, at doses of 10, 25 and 50 mg/kg.

KEYWORDS:

Diabetes; Flavonoids; Meta-analysis; Quercetin; Systematic review

PMID:
30735748
DOI:
10.1016/j.fct.2019.01.037
[Indexed for MEDLINE]

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