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Cell Stem Cell. 2019 Feb 7;24(2):203-205. doi: 10.1016/j.stem.2019.01.008.

Unraveling Difficult Answers: From Genotype to Phenotype in Coronary Artery Disease.

Author information

1
Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
2
Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: paul.burridge@northwestern.edu.

Abstract

Genome-wide association studies (GWASs) have robustly found a correlation between coronary artery disease (CAD) and an intergenic region at locus 9p21.3. However, the mechanistic implication of this association is unknown. Recently in Cell, Lo Sardo et al. used hiPSC genome editing to demonstrate how this locus contributes to CAD predisposition.

PMID:
30735646
DOI:
10.1016/j.stem.2019.01.008

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