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Chemistry. 2019 Mar 21;25(17):4315-4319. doi: 10.1002/chem.201806242. Epub 2019 Mar 1.

One-Pot Synthesis of DOX@Covalent Organic Framework with Enhanced Chemotherapeutic Efficacy.

Liu S1,2, Hu C1,2, Liu Y1, Zhao X1, Pang M1,2, Lin J1,2.

Author information

1
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
2
University of Science and Technology of China, Hefei, 230026, P. R. China.

Abstract

Covalent organic frameworks (COFs) have attracted great attention across diverse research fields. However, only a few reports about the biomedical application of COFs are found in the literature. Attributed to the highly porous and tunable structure, as well as good thermal stability, COFs show great potential as drug carriers for chemotherapy. In this work, doxorubicin (DOX) was successfully in situ loaded into a COF by a one-pot method for the first time. The resultant DOX@COF platform exhibited high drug-loading capacity (32.1 wt %) and pH-responsive release property. In vitro and in vivo experiments demonstrated its good biocompatibility and enhanced antitumor efficacy.

KEYWORDS:

antitumor; covalent organic frameworks; drug delivery; encapsulation; morphology control

PMID:
30735271
DOI:
10.1002/chem.201806242

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