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J Genet Eng Biotechnol. 2018 Dec;16(2):427-432. doi: 10.1016/j.jgeb.2018.09.002. Epub 2018 Dec 10.

Recent advances in stem cells therapy: A focus on cancer, Parkinson's and Alzheimer's.

Author information

1
Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Ahmed Zewail Road, October Gardens, 6th of October City, Giza 12578, Egypt.
2
Krebs Institute, Department of Molecular Biology and Biotechnology, Firth Court, University of Sheffield, S10 2TN Sheffield, UK.

Abstract

Stem cells serve as potential therapeutics due to their high proliferative capacity, low immunogenic reactivity and their differentiating capabilities. Several pre-clinical and early-stage clinical studies are carried out to treat genetic diseases, cancers and neurodegenerative disorders with promising preliminary results. However, there are still many challenges that scientists are trying to overcome such as the unclear expression profile of stem cells in vivo, the homing of stem cells to the site of injury and their potential immune-reactivity. Prospective research lies in gene editing of autologous stem cells in vitro and safe injection of these modified cells back into patients. Here, we review the clinical trials executed using stem cell therapy in an attempt to cure challenging diseases like cancer, Parkinson's and Alzheimer's diseases.

KEYWORDS:

Alzheimer’s disease; Cancer; Neurodegenerative disorders; Parkinson’s disease; Stem cells

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