Format

Send to

Choose Destination
J Pediatr. 2019 Apr;207:192-197.e1. doi: 10.1016/j.jpeds.2018.12.026. Epub 2019 Feb 4.

Use of a Probiotic to Enhance Iron Absorption in a Randomized Trial of Pediatric Patients Presenting with Iron Deficiency.

Author information

1
Children's Minnesota Sleep Center, Children's Minnesota, Minneapolis, MN.
2
Children's Minnesota Research Institute, Children's Minnesota, Minneapolis, MN.
3
Children's Minnesota Research Institute, Children's Minnesota, Minneapolis, MN. Electronic address: timothy.barnes@childrensmn.org.

Abstract

OBJECTIVE:

To evaluate the efficacy of low dose ferrous sulfate for the treatment of iron deficiency and if the probiotic Lactobacillus plantarum 299v (LP299v) enhances treatment.

STUDY DESIGN:

This randomized, double-blinded, controlled trial of the treatment of iron deficiency in children compared the use of low-dose ferrous sulfate (1-3 mg/kg/day), with or without probiotic (LP299v).

RESULTS:

Serum ferritin level increased in all children from a baseline of 23.7 ng/mL to 45.4 ng/mL after 6-8 weeks of treatment. There was no significant difference in the increase in serum ferritin in children taking the probiotic LP299v compared with controls (23.2 vs 20.0 ng/mL, respectively). Additionally, an increase in ferritin level was not significantly associated with probiotic use when controlling for other factors, including child weight and dosing. Overall, the treatments were well-tolerated, with mild side effects.

CONCLUSIONS:

Treatment with low-dose ferrous sulfate is well-tolerated and effective in correcting iron deficiency in children. However, the probiotic LP299v did not enhance treatment. Further attention should examine the dose-response effect in children, including an alternate day dosing schedule.

TRIAL REGISTRATION:

ClinicalTrials.gov: NCT01617044.

KEYWORDS:

adolescents; children; supplements

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center