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J Int Med Res. 2019 Feb 7:300060518819381. doi: 10.1177/0300060518819381. [Epub ahead of print]

Clinical prognostic significance of serum high mobility group box-1 protein in patients with community-acquired pneumonia.

Author information

1
1 Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
2
2 Department of Respiratory Medicine, The Second People's Hospital of Qinzhou, Qinzhou, Guangxi, China.

Abstract

OBJECTIVE:

To investigate the relationship between serum high mobility group box-1 protein (HMGB-1) levels and prognosis in patients with community-acquired pneumonia (CAP).

METHODS:

This prospective study included 35 patients who attended our hospital from January 2016 to December 2016. Pneumonia severity was defined by pneumonia severity index (PSI). Serum levels of C-reactive protein (CRP), cortisol, and HMGB-1 were analyzed in relation to disease severity and clinical outcome.

RESULTS:

High HMGB-1 levels were associated with high cortisol levels. High HMGB-1 and high cortisol were both significantly associated with high white blood cell count and high serum CRP, compared with low HMGB-1 and low cortisol, respectively. PSI score and 30-day mortality were also significantly higher in patients with high HMGB-1 or high cortisol levels compared with patients with low HMGB-1 or cortisol levels, respectively. CRP, cortisol, and HMGB-1 levels were all significantly higher in patients who died compared with survivors.

CONCLUSION:

HMGB-1 was associated with clinical outcomes and was an independent risk factor for 30-day mortality in patients with CAP. Serum HMGB-1 levels were also positively correlated with serum levels of cortisol. These results demonstrate a role for HMGB-1 in CAP, and suggest possible new therapeutic targets for patients with CAP.

KEYWORDS:

C-reactive protein; High mobility group box-1 protein; clinical outcome; community-acquired pneumonia; cortisol; prognosis

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