Send to

Choose Destination
J Appl Physiol (1985). 2019 Feb 7. doi: 10.1152/japplphysiol.01052.2018. [Epub ahead of print]

Role of heat shock proteins 70/90 in exercise physiology, exercise immunology and their diagnostic potential in sports.

Author information

Department of Exercise and Health, Leibniz University of Hannover, Germany.
Dept. of Exercise and Health, University of Hannover, Germany.
Institute of Biophysics and Center of Biomolecular Drug Research (BMWZ), Leibniz University Hannover, Germany.


Heat shock proteins (HSPs) are molecular chaperones facilitating the unfolding or folding of secondary structures of proteins, their client proteins, in cellular stress situations. Various internal and external physiological and mechanical stress factors induce a homeostatic imbalance followed by an increased expression of HSP70 and HSP90. Exercise is a stress factor, too, and its cumulative physiological perturbation manifests at a cellular level by threatening the protein homeostasis of various cell types. Consequently, an increase of HSP70/90 was described in plasma and mononuclear cells, various organs and tissues, such as muscle, liver, cardiac tissue, and brain, after an acute bout of exercise. The specific response of HSP70/90 seems to be strongly related to the modality of exercise with several dependent factors such as duration, intensity, exercise type, subjects' training status and environmental factors, e.g. temperature. It is suggested that HSP70/90 play a major role in immune regulation and cell protection during exercise and the efficiency of regeneration and reparation processes. During long-term training, HSP70/90 are involved in pre-conditioning and adaptation processes that might also be important for disease prevention and therapy. With regards to their highly sensitive and individual response to specific exercise and training modalities, this review discusses if and how HSP70 and HSP90 can be applied as biomarkers for monitoring exercise and training.


Stress proteins; biomarkers; inflammation; physical activity; recovery

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center