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Int J Rheum Dis. 2019 Apr;22(4):695-699. doi: 10.1111/1756-185X.13495. Epub 2019 Feb 6.

Prevalence and associated factors of small intestinal bacterial overgrowth among systemic sclerosis patients.

Author information

1
Faculty of Medicine, Division of Gastroenterology, Department of Medicine, Khon Kaen University, Khon Kaen, Thailand.
2
Faculty of Medicine, Division of Allergy-Immunology-Rheumatology, Department of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Abstract

BACKGROUND:

Small intestinal bacterial overgrowth (SIBO) results in nutrient malabsorption and malnutrition, thereby increasing the morbidity and mortality in systemic sclerosis (SSc) patients.

OBJECTIVES:

To evaluate the prevalence and associated factors of SIBO in SSc patients.

METHOD:

A cross-sectional study was conducted between July 2015 and January 2016 in SSc patients over 18, using the glucose H2 /CH4 breath test to evaluate SIBO.

RESULTS:

Eighty-nine SSc patients (30 male and 59 female) underwent the glucose H2 /CH4 breath test. The mean age was 54.4. Twelve participants were positive for the glucose H2 /CH4 breath test, yielding a SIBO prevalence of 13.5% (95% CI 7.2-22.4) among SSc patients. A multivariate analysis revealed that duration of disease >5 years was significantly associated with SIBO (adjusted odds ratio 9.38; 95% CI 1.09-80.47).

CONCLUSION:

The prevalence of SIBO, using the glucose H2 /CH4 breath test, is not common among Thai SSc patients. However, a positive result was associated with longer duration of disease.

KEYWORDS:

hydrogen breath test; scleroderma; small intestinal bacterial overgrowth; systemic sclerosis

PMID:
30729669
DOI:
10.1111/1756-185X.13495

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