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Methods Mol Biol. 2019;1914:331-342. doi: 10.1007/978-1-4939-8997-3_18.

Murine Models of Bone Sarcomas.

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INSERM, UMR1238, Bone Sarcoma and Remodeling of Calcified Tissues, Université de Nantes, Nantes Atlantique Universités, Nantes, France.
INSERM, U1238, University of Nantes, Nantes, France.
Department of Medicine, St. Vincent's Institute of Medical Research, St. Vincent's Hospital, University of Melbourne, Melbourne, VIC, Australia.
Centre for Craniofacial and Regenerative Biology, King's College London Guy's Hospital, London, UK.
Institut de Cancérologie de l'Ouest, INSERM, UMR1232, Université de Nantes, Université d'Angers, Tumour Heterogeneity and Precision Medicine, Nantes, France.


This chapter describes the procedures for inducing bone sarcoma in mice. Two models based on inoculation of cancer cells in paraosseous and intraosseous site will be described. In addition to providing technical aspects of anesthesia and surgical options, key information of cell preparation and postoperative follow-up will be discussed.


Bone sarcoma; Cell-injection; Chondrosarcoma; Ewing sarcoma; Genetically-engineered mouse models; Murine preclinical models; Osteosarcoma

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