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Exp Biol Med (Maywood). 2019 Feb 6:1535370219828706. doi: 10.1177/1535370219828706. [Epub ahead of print]

Hemorrhage simulated by lower body negative pressure provokes an oxidative stress response in healthy young adults.

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1 Department of Physiology & Anatomy, University of North Texas Health Science Center, Fort, TX 76107, USA.
2 Division of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.


We characterize the systemic oxidative stress response in young, healthy human subjects with exposure to simulated hemorrhage via application of lower body negative pressure (LBNP). Prior work has demonstrated that LBNP and actual blood loss evoke similar hemodynamic and immune responses (i.e. white blood cell count), but it is unknown whether LBNP elicits oxidative stress resembling that produced by blood loss. We show that LBNP induces a 29% increase in F2-isoprostanes, a systemic marker of oxidative stress. The findings of this investigation may have important implications for the study of hemorrhage using LBNP, including future assessments of targeted interventions that may reduce oxidative stress, such as novel fluid resuscitation approaches.


F2-isoprostanes; blood loss; cardiovascular; human subjects; lower body negative pressure; oxidative


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