Format

Send to

Choose Destination
J Leukoc Biol. 2019 Feb 6. doi: 10.1002/JLB.MR0818-319R. [Epub ahead of print]

Microglia in Alzheimer's disease: A target for immunotherapy.

Author information

1
Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, USA.

Abstract

Microglia are resident Mϕs of the CNS that play pleiotropic functions in brain development and homeostasis. Impaired microglial functions are thought to be involved in the onset and progression of various neurodevelopmental and neurodegenerative diseases. Thus, understanding microglia in these settings may indicate new approaches for therapeutic intervention. Here, we review recent evidence implicating microglia in Alzheimer's disease and discuss potential therapeutic strategies targeting microglia and their receptors in this disease.

KEYWORDS:

Alzheimer's disease; TREM2; immunotherapy; microglia; neuroinflammation; phagocytosis

PMID:
30725482
DOI:
10.1002/JLB.MR0818-319R

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center