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Rev Med Chil. 2018 Sep;146(9):1033-1040. doi: 10.4067/s0034-98872018000901033.

[Transbronchial cryobiopsies and cryotherapy in lung diseases].

[Article in Spanish]

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Servicio de Neumología, Universidad de Antioquia, Colombia.
Servicio de Neumología, Hospital Universitario Fundacion Favarolo, CABA, Argentina.
Facultad de Medicina, Universidad San Sebastián, Concepción, Chile.
Division of Pulmonary and Critical Care, Harvard Medical School, Massachusetts General Hospital, Boston, United States.
Division of Interventional Pulmonology and Thoracic Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, United States.
Division of Pulmonary and Critical Care Medicine, Mayo Clinic Jacksonville, Florida, United States.


Bronchoscopy cryoprobes are used for palliative treatment of endobronchial obstructions caused by tumors and removal of granulation tissue or foreign bodies. Currently this technology is also used for diagnosis of diffuse interstitial lung disease (ILD). The multidisciplinary team that establishes the clinical, radiological and histopathological correlation in ILD, decides about performing a surgical lung biopsy when the characteristics of the interstitial disease are not similar to Idiopathic Pulmonary Fibrosis (IPF). Although surgical lung biopsy is the gold standard for diagnosis, treatment, and prognosis, transbronchial cryo-biopsy has a high diagnostic yield, low morbidity and mortality rate, low rate of complications and lower cost. It is the diagnostic method of choice in ILD when it is available. Technological improvements with greater freezing power and tensile strength of the cryo probes, allow their use in cryotherapy and cryo-recanalization for occlusive airway tumors.

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