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J Agric Food Chem. 2019 Feb 27;67(8):2120-2126. doi: 10.1021/acs.jafc.8b06981. Epub 2019 Feb 14.

In Vivo Sampling: A Promising Technique for Detecting and Profiling Endogenous Substances in Living Systems.

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School of Chemistry , Sun Yat-sen University , Guangzhou , Guangdong 510275 , People's Republic of China.
Department of Radiology, Sun Yat-sen Memorial Hospital , Sun Yat-sen University , Guangzhou , Guangdong 510120 , People's Republic of China.
Department of Environmental Sciences , University of California, Riverside , Riverside , California 92521 , United States.


Endogenous substances, naturally occurring in living organisms, are critical components with physiological and biological functions. Discovery and quantitative measurement of endogenous substances in living biotas are important for food analysis, crop cultivation, and quality assessment. Low or non-invasive in vivo sampling techniques offer the advantages of minimal perturbation to the investigated system and potentially obtain more accurate feedback compared to in vitro sampling. In this perspective, we summarize the up-to-date progress in the development of microdialysis and solid-phase microextraction as valuable tools for in vivo sampling of endogenous substances in food and agriculture chemistry. We discuss their feasibility for on-site and real-time in vivo monitoring and highlight the prospects in searching for highly specific coatings, miniaturized sampling devices, and instruments that well meet the trend for high-efficient and high-throughput analyses.


endogenous substances; food analysis; in vivo sampling; microdialysis; solid-phase microextraction

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