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Epilepsy Behav Case Rep. 2018 Nov 24;11:58-66. doi: 10.1016/j.ebcr.2018.11.003. eCollection 2019.

Longitudinal brain functional and structural connectivity changes after hemispherotomy in two pediatric patients with drug-resistant epilepsy.

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Guangdong Provincial Key Laboratory of Medical Biomechanics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Department of Pediatric Neurosurgery, Shenzhen Children's Hospital, Shenzhen, China.


The main focus of the present study was to explore the longitudinal changes in the brain executive control system and default mode network after hemispherotomy. Resting-state functional magnetic resonance imaging and diffusion tensor imaging were collected in two children with drug-resistnt epilepsy underwent hemispherotomy. Two patients with different curative effects showed different trajectories of brain connectivity after surgery. The failed hemispherotomy might be due to the fact that the synchrony of epileptic neurons in both hemispheres is preserved by residual neural pathways. Loss of interhemispheric correlations with increased intrahemispheric correlations can be considered as neural marker for evaluating the success of hemispherotomy.


Diffusion tensor imaging; Functional connectivity; Hemispherotomy; Medically intractable epilepsy children; Probabilistic fiber tracking; Resting-state fMRI

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