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Gene. 1988 Dec 20;73(2):259-71.

Conserved sequences and structures of group I introns: building an active site for RNA catalysis--a review.

Author information

1
Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309-0215.

Abstract

Group I introns fold to form an active site to mediate their own RNA splicing. Sequence elements conserved among the available set of 66 group I introns are compiled. Comparative sequence analysis leads to the prediction of some conserved structural features that have not been widely appreciated. The possible significance of conserved nucleotides within base-paired duplexes is discussed; they might be involved in base triplets or alternate pairing interactions.

PMID:
3072259
DOI:
10.1016/0378-1119(88)90492-1
[Indexed for MEDLINE]

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