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Biol Trace Elem Res. 2019 Feb 5. doi: 10.1007/s12011-019-1656-3. [Epub ahead of print]

Cadmium Exposure and Blood Telomere Length in Female University Students in Japan.

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Department of Human Ecology, School of International Health, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Department of Anthropology, University of Washington, Seattle, USA.
Department of Nursing, Tokyo Healthcare University, Tokyo, Japan.
National Environmental Research and Training Institute, Tokorozawa City, Saitama, Japan.
Faculty of Life Sciences, Toyo University, 1-1-1 Izumino, Itakura, Ora, Gunma, 374-0193, Japan.
Faculty of Life Sciences, Toyo University, 1-1-1 Izumino, Itakura, Ora, Gunma, 374-0193, Japan.


Cadmium is a toxic metal found ubiquitously throughout the world. Our study evaluated whether cadmium exposure was associated with telomere length in 73 female university students. Determination of telomere length was performed by quantitative polymerase chain reaction using DNA in blood. Urinary cadmium concentration was measured by inductively coupled plasma mass spectrometry. The students' physiological attributes and lifestyle were surveyed by means of a self-administered questionnaire. The geometric mean of urinary cadmium concentration was 0.312 μg/g creatinine, which was lower than the levels previously reported for Japan. Urinary cadmium concentration was not significantly associated with telomere length, though the exposure level of the present subjects was similar to that of previous study subjects which found significantly negative associations. It is possible that other factors affected telomere length in this study population.


Blood telomere length; Cadmium; Female university student; Japan


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