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Angew Chem Int Ed Engl. 2019 Mar 26;58(14):4581-4586. doi: 10.1002/anie.201814320. Epub 2019 Feb 27.

Metabolically Active, Fully Hydrolysable Polymersomes.

Author information

1
Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, OX1 3TA, UK.
2
Department of Chemistry and Institute of Physics of Living Systems, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
3
Institute for Bioengineering of Catalonia, The Barcelona Institute of Science and Technology, 08028, Barcelona, Spain.
4
Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Portugal.
5
EPSRC/Jeol Centre for Liquid Phase Electron Microscopy, University College London, London, WC1H 0AJ, UK.

Abstract

The synthesis and aqueous self-assembly of a new class of amphiphilic aliphatic polyesters are presented. These AB block polyesters comprise polycaprolactone (hydrophobe) and an alternating polyester from succinic acid and an ether-substituted epoxide (hydrophile). They self-assemble into biodegradable polymersomes capable of entering cells. Their degradation products are bioactive, giving rise to differentiated cellular responses inducing stromal cell proliferation and macrophage apoptosis. Both effects emerge only when the copolymers enter cells as polymersomes and their magnitudes are size dependent.

KEYWORDS:

cells; drug discovery; polymers; ring opening; self-assembly

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