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Mol Neurobiol. 2019 Sep;56(9):6080-6094. doi: 10.1007/s12035-019-1497-2. Epub 2019 Feb 4.

Current Understanding of the Role of Neuronal Calcium Sensor 1 in Neurological Disorders.

Author information

1
Department of Physiology, Faculty of Medicine, University of Toronto, 3306 MSB, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
2
Department of Physiology, Faculty of Medicine, University of Toronto, 3306 MSB, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. zp.feng@utoronto.ca.

Abstract

Neuronal calcium sensor 1 (NCS-1) is a high-affinity calcium-binding protein and its ubiquitous expression in the nervous system implies a wide range of functions. To date, it has been implicated in regulation of calcium channels in both axonal growth cones and presynaptic terminals, pre- and postsynaptic plasticity mechanisms, learning and memory behaviors, dopaminergic signaling, and axonal regeneration. This review summarizes these functions and relates them to several diseases in which NCS-1 plays a role, such as schizophrenia and bipolar disorder, X-linked mental retardation and fragile X syndrome, and spinal cord injury. Many questions remain unanswered about the role of NCS-1 in these diseases, particularly as the genetic factors that control NCS-1 expression in both normal and diseased states are still poorly understood. The review further identifies the therapeutic potential of manipulating the interaction of NCS-1 with its many targets and suggests directions for future research on the role of NCS-1 in these disorders.

KEYWORDS:

Bipolar disorder; Calcium-binding proteins; Frequenin; NCS-1; Schizophrenia; X-linked mental retardation

PMID:
30719643
DOI:
10.1007/s12035-019-1497-2

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