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Sci Rep. 2019 Feb 4;9(1):1150. doi: 10.1038/s41598-018-37640-1.

Electrospun patterned porous scaffolds for the support of ovarian follicles growth: a feasibility study.

Author information

1
Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, 91058, Erlangen, Germany. liliana.liverani@fau.de.
2
Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander-Universität Erlangen-Nürnberg, Comprehensive Cancer Center ER-EMN, 91054, Erlangen, Germany.
3
Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, 91058, Erlangen, Germany.
4
Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander-Universität Erlangen-Nürnberg, Comprehensive Cancer Center ER-EMN, 91054, Erlangen, Germany. ralf.dittrich@uk-erlangen.de.

Abstract

Recently, the interest of the scientific community is focused on the application of tissue engineering approach for the fertility restoration. In this paper innovative patterned electrospun fibrous scaffolds were fabricated and used as 3D system for porcine follicles culture. The obtained scaffolds demonstrated to be a suitable support which did not alter or interfere with the typical spherical follicles morphology. The fibrillar structure of the scaffolds mimics the morphology of the healthy native tissue. The use of porcine follicles implied many advantages respect to the use of mouse model. Relevant results showed that more than the scaffold pattern and struts dimension, the selection of proper biomaterials improve the follicles adhesion and development.

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