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Transl Psychiatry. 2019 Feb 4;9(1):72. doi: 10.1038/s41398-019-0382-0.

Structural neuroimaging correlates of social deficits are similar in autism spectrum disorder and attention-deficit/hyperactivity disorder: analysis from the POND Network.

Author information

1
Department of Psychiatry, University of Toronto, Toronto, ON, Canada. danielle.baribeau@mail.utoronto.ca.
2
Clinical Research Services, The Hospital for Sick Children, and the Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
3
The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada.
4
Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada.
5
The McLaughlin Centre and the Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
6
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
7
Department of Psychiatry, Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
8
Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine and Department of Psychiatry and Medical Genetics, University of Calgary, Calgary, AL, Canada.
9
The Centre for Addiction and Mental Health, Toronto, ON, Canada.
10
Department of Psychiatry, Western University and Children's Health Research Institute, London, ON, Canada.
11
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
12
Department of Paediatrics, University of Toronto, Toronto, ON, Canada.
13
Autism Research Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.
14
University of Toronto, Institute of Biomaterial and Biomedical Engineering, Toronto, ON, Canada.
15
Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

Abstract

Autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD) have been associated with difficulties recognizing and responding to social cues. Neuroimaging studies have begun to map the social brain; however, the specific neural substrates contributing to social deficits in neurodevelopmental disorders remain unclear. Three hundred and twelve children underwent structural magnetic resonance imaging of the brain (controls = 32, OCD = 44, ADHD = 77, ASD = 159; mean age = 11). Their social deficits were quantified on the Social Communication Questionnaire (SCQ) and the Reading the Mind in the Eyes Test (RMET). Multivariable regression models were used to examine the structural neuroimaging correlates of social deficits, with both a region of interest and a whole-brain vertex-wise approach. For the region of interest analysis, social brain regions were grouped into three networks: (1) lateral mentalization (e.g., temporal-parietal junction), (2) frontal cognitive (e.g., orbitofrontal cortex), and (3) subcortical affective (e.g., limbic system) regions. Overall, social communication deficits on the SCQ were associated with thinner cortices in the left lateral regions and the right insula, and decreased volume in the ventral striatum, across diagnostic groups (p = 0.006 to <0.0001). Smaller subcortical volumes were associated with more severe social deficits on the SCQ in ASD and ADHD, and less severe deficits in OCD. On the RMET, larger amygdala/hippocampal volumes were associated with fewer deficits across groups. Overall, patterns of associations were similar in ASD and ADHD, supporting a common underlying biology and the blurring of the diagnostic boundaries between these disorders.

PMID:
30718456
PMCID:
PMC6361977
DOI:
10.1038/s41398-019-0382-0
[Indexed for MEDLINE]
Free PMC Article

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