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Proc Natl Acad Sci U S A. 2019 Feb 4. pii: 201818504. doi: 10.1073/pnas.1818504116. [Epub ahead of print]

Convergent gene losses illuminate metabolic and physiological changes in herbivores and carnivores.

Hecker N1,2,3, Sharma V1,2,3, Hiller M4,2,3.

Author information

1
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
2
Max Planck Institute for the Physics of Complex Systems, 01307 Dresden, Germany.
3
Center for Systems Biology Dresden, 01307 Dresden, Germany.
4
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany; hiller@mpi-cbg.de.

Abstract

The repeated evolution of dietary specialization represents a hallmark of mammalian ecology. To detect genomic changes that are associated with dietary adaptations, we performed a systematic screen for convergent gene losses associated with an obligate herbivorous or carnivorous diet in 31 placental mammals. For herbivores, our screen discovered the repeated loss of the triglyceride lipase inhibitor PNLIPRP1, suggesting enhanced triglyceride digestion efficiency. Furthermore, several herbivores lost the pancreatic exocytosis factor SYCN, providing an explanation for continuous pancreatic zymogen secretion in these species. For carnivores, we discovered the repeated loss of the hormone-receptor pair INSL5-RXFP4 that regulates appetite and glucose homeostasis, which likely relates to irregular feeding patterns and constant gluconeogenesis. Furthermore, reflecting the reduced need to metabolize plant-derived xenobiotics, several carnivores lost the xenobiotic receptors NR1I3 and NR1I2 Finally, the carnivore-associated loss of the gastrointestinal host defense gene NOX1 could be related to a reduced gut microbiome diversity. By revealing convergent gene losses associated with differences in dietary composition, feeding patterns, and gut microbiomes, our study contributes to understanding how similar dietary specializations evolved repeatedly in mammals.

KEYWORDS:

carnivorous diet; convergent gene loss; herbivorous diet; metabolism; physiology

PMID:
30718421
DOI:
10.1073/pnas.1818504116
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Conflict of interest statement

The authors declare no conflict of interest.

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