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J Bacteriol. 2019 Feb 4. pii: JB.00019-19. doi: 10.1128/JB.00019-19. [Epub ahead of print]

One Basic Blueprint, Many Different Motors.

Author information

1
Department of Biology, Texas A&M University, College Station, TX 77843-3258 mike@bio.tamu.edu.

Abstract

The cytoplasmic C-ring of the bacterial flagellum is known as the switch complex. It binds the response regulator phospho-CheY to control the direction of flagellar rotation. The C-ring of enteric bacteria is well characterized. However, no Gram-positive switch complex had been modeled. Ward et al. propose a structure for the Bacillus subtilis switch complex based on extensive biochemical studies. The work demonstrates that a similar architecture can accommodate different proteins and a reversed signaling logic.

PMID:
30718302
DOI:
10.1128/JB.00019-19

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