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J Clin Med. 2019 Feb 3;8(2). pii: E179. doi: 10.3390/jcm8020179.

Peptic Ulcer Disease: A Brief Review of Conventional Therapy and Herbal Treatment Options.

Author information

1
Department of Pharmacology and Biochemistry, Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia. lucija.kuna@fdmz.hr.
2
Department of Pathophysiology and Physiology with Immunology, Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia. jelena.jakab@fdmz.hr.
3
Department of Internal Medicine, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia. jelena.jakab@fdmz.hr.
4
Department of Pathophysiology and Physiology with Immunology, Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia. robert.smolic@fdmz.hr.
5
Department of Pharmacology, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia. robert.smolic@fdmz.hr.
6
Department of Internal Medicine, University Hospital Osijek, 31000 Osijek, Croatia. robert.smolic@fdmz.hr.
7
Department of Pharmacology and Biochemistry, Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia. nikola.rlucic@gmail.com.
8
Department of Pathophysiology and Physiology with Immunology, Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia. aleksandar.vcev@fdmz.hr.
9
Department of Internal Medicine, University Hospital Osijek, 31000 Osijek, Croatia. aleksandar.vcev@fdmz.hr.
10
Department of Pharmacology and Biochemistry, Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia. martina.smolic@mefos.hr.
11
Department of Pharmacology, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia. martina.smolic@mefos.hr.

Abstract

Peptic ulcer is a chronic disease affecting up to 10% of the world's population. The formation of peptic ulcers depends on the presence of gastric juice pH and the decrease in mucosal defenses. Non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori (H. pylori) infection are the two major factors disrupting the mucosal resistance to injury. Conventional treatments of peptic ulcers, such as proton pump inhibitors (PPIs) and histamine-2 (H2) receptor antagonists, have demonstrated adverse effects, relapses, and various drug interactions. On the other hand, medicinal plants and their chemical compounds are useful in the prevention and treatment of numerous diseases. Hence, this review presents common medicinal plants that may be used for the treatment or prevention of peptic ulcers.

KEYWORDS:

Helicobacter pylori infection; herbal treatment; peptic ulcer disease

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