Iron(III)-Catalyzed Highly Regioselective Halogenation of 8-Amidoquinolines in Water

Molecules. 2019 Feb 1;24(3):535. doi: 10.3390/molecules24030535.

Abstract

A simple protocol of iron(III)-catalyzed halogenation of 8-amidoquinolines in water under mild conditions was developed, affording the 5-halogenlated products in good to excellent yields up to 98%. The reaction mechanism most likely involves a single-electron transfer (SET) process.

Keywords: 8-amidoquinoline; catalysis; iron; water.

MeSH terms

  • Amides / chemical synthesis*
  • Catalysis
  • Chemistry Techniques, Synthetic / methods
  • Chlorides / chemistry*
  • Ferric Compounds / chemistry*
  • Halogenation
  • Molecular Structure
  • Nitrates / chemistry*
  • Quinolines / chemical synthesis*
  • Stereoisomerism
  • Water / chemistry*

Substances

  • Amides
  • Chlorides
  • Ferric Compounds
  • Nitrates
  • Quinolines
  • Water
  • ferric nitrate
  • ferric chloride