Abstract
A simple protocol of iron(III)-catalyzed halogenation of 8-amidoquinolines in water under mild conditions was developed, affording the 5-halogenlated products in good to excellent yields up to 98%. The reaction mechanism most likely involves a single-electron transfer (SET) process.
Keywords:
8-amidoquinoline; catalysis; iron; water.
MeSH terms
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Amides / chemical synthesis*
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Catalysis
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Chemistry Techniques, Synthetic / methods
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Chlorides / chemistry*
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Ferric Compounds / chemistry*
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Halogenation
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Molecular Structure
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Nitrates / chemistry*
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Quinolines / chemical synthesis*
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Stereoisomerism
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Water / chemistry*
Substances
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Amides
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Chlorides
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Ferric Compounds
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Nitrates
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Quinolines
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Water
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ferric nitrate
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ferric chloride