Format

Send to

Choose Destination
J Clin Endocrinol Metab. 2019 Feb 1. doi: 10.1210/jc.2018-02501. [Epub ahead of print]

Childhood exposure to passive smoking and bone health in adulthood. The Cardiovascular Risk in Young Finns Study.

Author information

1
Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Finland.
2
Murdoch Childrens Research Institute, Parkville, Victoria, Australia.
3
Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
4
Department of Food and Nutrition, University of Helsinki, Finland.
5
UKK-institute, Tampere, Finland.
6
Division of Nutrition, Department of Applied Chemistry and Microbiology, University of Helsinki, Finland.
7
Department of Pediatric Cardiology, Hospital for Children and Adolescents, University of Helsinki, Finland.
8
Department of Clinical Physiology, University of Eastern Finland and Kuopio University Hospital, Finland.
9
Royal Children's Hospital, Parkville, Victoria, Australia.
10
Department of Pediatrics, Tampere University and Tampere University Hospital, Finland.
11
Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center - Tampere, Tampere University, Tampere, Finland.
12
Vaasa Central Hospital, Finland.
13
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland.
14
Joint Clinical Biochemistry Laboratory of University of Turku and Turku University Hospital, Turku, Finland.
15
Department of Clinical Physiology, Tampere University Hospital and Tampere University, Finland.
16
Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
17
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Finland.

Abstract

Context:

Passive smoke exposure has been linked with the risk of osteoporosis in adults.

Objective:

We aimed to examine the independent effects of exposure to passive smoking in childhood on adult bone health.

Design/Setting:

Longitudinal, the Cardiovascular Risk in Young Finns Study.

Participants:

Study cohort included 1422 individuals followed up for 28 years since baseline in 1980 (age 3-18 years). Exposure to passive smoking was determined in childhood. In adulthood, peripheral bone traits were assessed with quantitative computed tomography (pQCT) at the tibia and radius, and calcaneal mineral density was estimated with quantitative ultrasound. Fracture data was gathered by questionnaires.

Results:

Parental smoking in childhood was associated with lower pQCT derived bone sum index in adulthood (β±SE -0.064±0.023 per smoking parent, P=0.004) in multivariate models adjusted for age, sex, active smoking, BMI, serum 25-OH vitamin D concentration, physical activity, and parental socioeconomic position. Similarly, parental smoking was associated with lower heel ultrasound estimated bone mineral density in adulthood (β±SE -0.097±0.041 per smoking parent, P=0.02). Parental smoking was also associated with the incidence of low-energy fractures (odds ratio 1.28, 95% confidence interval 1.01-1.62). Individuals with elevated cotinine levels (3-20 ng/ml) in childhood had lower bone sum index with pQCT (β±SE -0.206±0.057, P=0.0003). Children whose parents smoked and had high cotinine levels (3-20 ng/ml) had significantly lower pQCT derived bone sum index compared to those with smoking parents but low cotinine levels (<3ng/ml) (β±SE -0.192±0.072, P=0.008).

Conclusions and relevance:

Children of parents who smoke have evidence of impaired bone health in adulthood.

PMID:
30715377
DOI:
10.1210/jc.2018-02501

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center