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J Infect Dis. 2019 Apr 8;219(Supplement_1):S21-S29. doi: 10.1093/infdis/jiz010.

Antibody Determinants of Influenza Immunity.

Crowe JE1,2,3.

Author information

1
Vanderbilt Vaccine Center, Nashville, Tennessee.
2
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.
3
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.

Abstract

Understanding antigenic variation in influenza virus strains and how the human immune system recognizes strains are central challenges for vaccinologists. Antibodies directed to the 2 major viral surface membrane proteins, hemagglutinin (HA) and neuraminidase (NA), mediate protection against reinfection following natural infection or vaccination, but HA and NA protein sequences in field strains are highly variable. The central questions are how to achieve protective antibody responses in a higher proportion of individuals and how to induce responses with more breadth and durability. Studies using isolation of human monoclonal antibodies followed by structural and functional characterization revealed conserved antigenic sites recognized by broadly cross-reactive antibodies. The antigenic landscape on HA and NA proteins is coming into focus to inform studies of the correlates and mechanisms of immunity. Understanding the antibody determinants of influenza immunity points the way toward development and testing of next-generation vaccines with potential to confer broadly protective immunity.

KEYWORDS:

antibodies; antibodies, neutralizing; antibody-dependent cell cytotoxicity; hemagglutination inhibition tests; influenza A virus; orthomyxoviridae infections; viral

PMID:
30715373
PMCID:
PMC6452307
[Available on 2020-04-08]
DOI:
10.1093/infdis/jiz010

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