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Curr Drug Deliv. 2019;16(5):444-460. doi: 10.2174/1567201816666190201143457.

Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies.

Author information

1
School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University of Technology, Perth, Australia.
2
Diamantina Institute, The University of Queensland, Translational Research Institute, QLD, 4102, Australia.
3
School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia.

Abstract

This overview on skin delivery considers the evolution of the principles of percutaneous absorption and skin products from ancient times to today. Over the ages, it has been recognised that products may be applied to the skin for either local or systemic effects. As our understanding of the anatomy and physiology of the skin has improved, this has facilitated the development of technologies to effectively and quantitatively deliver solutes across this barrier to specific target sites in the skin and beyond. We focus on these technologies and their role in skin delivery today and in the future.

KEYWORDS:

History; follicular transport; microneedles; minimally invasive; nanotechnology; physical enhancement; skin delivery; stratum corneum; targeted delivery; transdermal technologies; wearable devices.

PMID:
30714524
PMCID:
PMC6637104
DOI:
10.2174/1567201816666190201143457
[Indexed for MEDLINE]
Free PMC Article

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