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Curr Drug Deliv. 2019;16(5):400-429. doi: 10.2174/1567201816666190201144815.

Nanomedicines as Drug Delivery Carriers of Anti-Tubercular Drugs: From Pathogenesis to Infection Control.

Author information

1
Faculty of Pharmacy, S. Sinha College, Aurangabad-824101, Bihar, India.
2
Department of Pharmaceutical Sciences and technology, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India.
3
Department of Chemistry, VIT University, Vellore 632014, Tamilnadu, India.
4
Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Abstract

In spite of advances in tuberculosis (TB) chemotherapy, TB is still airborne deadly disorder as a major issue of health concern worldwide today. Extensive researches have been focused to develop novel drug delivery systems to shorten the lengthy therapy approaches, prevention of relapses, reducing dose-related toxicities and to rectify technologically related drawbacks of anti-tubercular drugs. Moreover, the rapid emergence of drug resistance, poor patient compliance due to negative therapeutic outcomes and intracellular survival of Mycobacterium highlighted to develop carrier with optimum effectiveness of the anti-tubercular drugs. This could be achieved by targeting and concentrating the drug on the infection reservoir of Mycobacterium. In this article, we briefly compiled the general aspects of Mycobacterium pathogenesis, disease treatment along with progressive updates in novel drug delivery carrier system to enhance therapeutic effects of drug and the high level of patient compliance. Recently developed several vaccines might be shortly available as reported by WHO.

KEYWORDS:

Clinical therapy; Tuberculosis; diagnosis; nanomedicine; pathogenesis; review.

PMID:
30714523
PMCID:
PMC6637229
DOI:
10.2174/1567201816666190201144815
[Indexed for MEDLINE]
Free PMC Article

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