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Cephalalgia. 2019 Feb 2:333102419828989. doi: 10.1177/0333102419828989. [Epub ahead of print]

Parental migraine in relation to migraine in offspring: Family linkage analyses from the HUNT Study.

Author information

1
1 Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
2
2 Research and Communication Unit for Musculoskeletal Health, Division of Clinical Neuroscience, Oslo University Hospital, Ullevål, Oslo, Norway.
3
3 Department of Neurology, Oslo University Hospital, Oslo, Norway.
4
4 Norwegian Centre for Violence and Traumatic Stress Studies, Oslo, Norway.
5
5 Department of Neuromedicine and Movement Science, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
6
6 Norwegian Advisory Unit on Headache, Department of Neurology and Clinical Neurophysiology, St. Olavs University Hospital Trondheim, Norway.

Abstract

BACKGROUND:

Migraine is known to run in families. While some clinical studies have indicated that migraine is disproportionally transmitted through the maternal line, this has not been examined in a population-based setting.

METHODS:

We utilized a large, population-based cohort study from Norway, the HUNT Study. Using a cross-sectional design, our sample consisted of 13,731 parents and 8970 offspring. Logistic regression was used to calculate odds ratios with 95% confidence intervals for active migraine and non-migrainous headache in offspring, given active maternal or paternal headache.

RESULTS:

There was a significant association between maternal migraine and offspring migraine (odds ratio 2.76, 95% confidence interval 2.18-3.51). A weaker association ( p = 0.004 for comparison with maternal migraine) was found between paternal migraine and offspring migraine (odds ratio 1.67, 95% confidence interval 1.33-2.28). For non-migrainous headache, there was a significant association between mothers and offspring (odds ratio 1.25, 95% confidence interval 1.10-1.43), but not between fathers and offspring.

CONCLUSIONS:

Parental migraine is associated with offspring migraine, with a stronger association for maternal migraine. This may indicate maternal-specific transmission.

KEYWORDS:

Migraine; all headache; epidemiology

PMID:
30714392
DOI:
10.1177/0333102419828989

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