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Med Gas Res. 2019 Jan 9;8(4):176-180. doi: 10.4103/2045-9912.248270. eCollection 2018 Oct-Dec.

The role of hydrogen in Alzheimer's disease.

Author information

1
Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
2
Department of Neurosurgery & Brain and Nerve Research Laboratory, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.

Abstract

Alzheimer's disease is one of the most common neurodegenerative diseases in the elderly. It is often manifested as learning and memory impairment, cognitive function decline, normal social and emotional disorders. However, for this high-risk common disease, there is currently no effective treatment, which has plagued many clinicians. As a new type of medical therapeutic gas, hydrogen has attracted much attention recently. As a recognized reducing gas, hydrogen has shown great anti-oxidative stress and anti-inflammatory effect in many cerebral disease models. It can ameliorate neuronal damage, maintain the number of neurons, prolong the lifespan of neurons, and ultimately inhibit disease progression. Therefore, the role and mechanism of hydrogen in the pathological process of Alzheimer's disease will be discussed in this paper.

KEYWORDS:

Alzheimer's disease; anti-inflammation; anti-oxidative stress; experimental research; hydrogen; neuroprotection; therapeutic implications; underlying mechanism

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