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J Contemp Dent Pract. 2018 Dec 1;19(12):1501-1505.

Evaluation of Effect of Glucosamine-Chondroitin Sulfate, Tramadol, and Sodium Hyaluronic Acid on Expression of Cytokine Levels in Internal Derangement of Temporomandibular Joint.

Author information

1
Deptartment of Oral and Maxillofacial Surgery, Bhabha College of Dental Sciences, Bhopal, Madhya Pradesh, India.
2
Deptartment of Oral and Maxillofacial Surgery, ACPM Dental College, Dhule, Maharashtra, India.
3
Deptartment of Oral and Maxillofacial Surgery, Terna Dental College, Navi Mumbai, Maharashtra, India.
4
Deptartment of Public Health Dentistry, Bhabha College of Dental Sciences, Bhopal, Madhya Pradesh, India, Phone: +917303320242, e-mail: drjunaid.kapadia@gmail.com.

Abstract

AIM:

Evaluation of the effect of glucosamine-chondroitin combination, tramadol, and sodium hyaluronic acid in temporomandibular joint (TMJ) disorders and its impact on the expression of various cytokines such as IL-6, IL-1β, TNF-α, and PGE2.

MATERIALS AND METHODS:

The present study was conducted on 60 patients (males-30, females-30) suffering from internal derangement such as disc displacement with reduction of TMJ. The patients were divided into three groups of 20 each. Group I received a combination of 1.5g of glucosamine and 1.2 g of chondroitin sulfate per day and group II received 50 mg tramadol HCL peroral. Group III received sodium hyaluronate 10 mg/mL, 2 mL injection syringe on each joint. Pain (VAS) scale and maximum mouth opening (MMO) was measured. The level of IL-6, IL-1β, TNF-α, and PGE2 levels were measured using Enzyme-linked immuno sorbent assay (ELISA).

RESULTS:

There was an improvement in maximum mouth opening in all three groups (p < 0.05). There was a reduction in pain in all groups. IL- 1β, TNF-α, and PGE2 leve ls showed reduction while IL-6 showed an increase in value in group II and III.

CONCLUSION:

The efficacy of glucosamine chondroitin sulfate , tramadol and hyaluronic acid in TMJ disorders has been found to be effective.

CLINICAL SIGNIFICANCE:

IL-6, IL-1β, TNF-α, and PGE2 levels indicate the risk of TMJ disorders. Thus earlier assessment of their levels helps in diagnosis, and better management may be done.

KEYWORDS:

Chondroitin sulfate; Glucosamine; TMJ Tramadol.

PMID:
30713180

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