Format

Send to

Choose Destination
Trends Endocrinol Metab. 2019 Apr;30(4):227-229. doi: 10.1016/j.tem.2019.01.006. Epub 2019 Jan 31.

Anticatabolic Effects of Ketone Bodies in Skeletal Muscle.

Author information

1
Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
2
National Institute for Cellular Biotechnology, School of Health and Human Performance, Dublin City University, Glasnevin, Dublin 9, Ireland. Electronic address: brendan.egan@dcu.ie.

Abstract

The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) are the subject of renewed interest given recently established pleiotropic effects regulating inflammation, oxidative stress, and gene expression. Anticatabolic effects of β-hydroxybutyrate have recently been demonstrated in human skeletal muscle under inflammatory insult, thereby expanding upon the wide-ranging therapeutic applications of nutritional ketosis.

KEYWORDS:

acetoacetate; atrophy; cachexia; inflammation; muscle protein breakdown; β-hydroxybutyrate

PMID:
30712977
DOI:
10.1016/j.tem.2019.01.006

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center