Update on Lipomatous Tumors with Emphasis on Emerging Entities, Unusual Anatomic Sites, and Variant Histologic Patterns

John S A Chrisinger

doi:10.1016/j.path.2018.11.001

Update on Lipomatous Tumors with Emphasis on Emerging Entities, Unusual Anatomic Sites, and Variant Histologic Patterns

Surg Pathol Clin. 2019 Mar;12(1):21-33. doi: 10.1016/j.path.2018.11.001.

Author

John S A Chrisinger¹

Affiliation

¹ Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8118, St Louis, MO, USA. Electronic address: jschrisi@wustl.edu.

PMID: 30709444
DOI: 10.1016/j.path.2018.11.001

Abstract

This article reviews the histologic patterns of spindle cell/pleomorphic lipoma, well-differentiated liposarcoma, and dedifferentiated liposarcoma in the context of both usual and atypical anatomic presentation. The utility of molecular and immunohistochemical diagnostic modalities to distinguish these entities is described. In addition, more recently described and controversial entities, including atypical spindle cell lipomatous tumor and anisometric cell lipoma, are discussed.

Keywords: Anisometric cell lipoma; Atypical spindle cell lipomatous tumor; Dysplastic lipoma; Fibrosarcoma-like lipomatous neoplasm; Liposarcoma; Pleomorphic lipoma; Spindle cell lipoma.

Publication types

Review

MeSH terms

Biomarkers, Tumor
Humans
Immunohistochemistry
Lipoma / diagnosis*
Lipoma / genetics
Lipoma / pathology*
Liposarcoma / diagnosis*
Liposarcoma / genetics
Liposarcoma / pathology*
Neoplasm Recurrence, Local / pathology
Soft Tissue Neoplasms / diagnosis*
Soft Tissue Neoplasms / genetics
Soft Tissue Neoplasms / pathology*
Terminology as Topic

Substances

Biomarkers, Tumor